LMPD Database

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LMP012523

UniProt Annotations

Entry Information
Gene Namesterol carrier protein 2
Protein EntryNLTP_RAT
UniProt IDP11915
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative initiation; Named isoforms=2; Name=SCPx; IsoId=P11915-1; Sequence=Displayed; Name=SCP2; IsoId=P11915-2; Sequence=VSP_018897; Note=Mitochondrial precursor. Contains a mitochondrial transit peptide at positions 405-424 (Potential). ;
Catalytic Activity3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha- trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.
FunctionMediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
Sequence CautionSequence=AAA40623.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA43060.1; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 SCP2 domain
SimilarityIn the N-terminal section; belongs to the thiolase family
Subcellular LocationCytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Subcellular LocationIsoform SCP2: Mitochondrion .
Subcellular LocationIsoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import
SubunitInteracts with PEX5
Tissue SpecificityLiver > intestine > brain > lung, colon, stomach, spleen, kidney, heart and ovary.