LMPD Database

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LMP012530

UniProt Annotations

Entry Information
Gene Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Protein Entry1433F_RAT
UniProt IDP68511
SpeciesRat
Comments
Comment typeDescription
FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)
InteractionQ3MUI1:Numb; NbExp=3; IntAct=EBI-444647, EBI-7007865;
PtmPhosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion
SimilarityBelongs to the 14-3-3 family
Subcellular LocationCytoplasm.
SubunitHomodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with ARHGEF28 and CDK16. Interacts with GAB2 (By similarity). Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1 (By similarity)