LMPD Database

LMP012535

Gene Information

Entrez Gene ID	25608
Gene Name	leptin
Gene Symbol	Lep
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0005615	IDA:HGNC	C	extracellular space
GO:0005125	TAS:RGD	F	cytokine activity
GO:0005179	IDA:RGD	F	hormone activity
GO:0051428	IDA:RGD	F	peptide hormone receptor binding
GO:0060612	IEA:Ensembl	P	adipose tissue development
GO:0008343	ISS:HGNC	P	adult feeding behavior
GO:0008206	IEA:Ensembl	P	bile acid metabolic process
GO:0035630	IDA:RGD	P	bone mineralization involved in bone maturation
GO:0019933	TAS:RGD	P	cAMP-mediated signaling
GO:0003300	IDA:RGD	P	cardiac muscle hypertrophy
GO:0071298	IEP:RGD	P	cellular response to L-ascorbic acid
GO:0071300	IEP:RGD	P	cellular response to retinoic acid
GO:0021954	IEA:Ensembl	P	central nervous system neuron development
GO:0008203	IEA:Ensembl	P	cholesterol metabolic process
GO:0007623	IEP:RGD	P	circadian rhythm
GO:0042755	IEA:Ensembl	P	eating behavior
GO:0006112	IDA:RGD	P	energy reserve metabolic process
GO:0006635	IEA:Ensembl	P	fatty acid beta-oxidation
GO:0009062	IDA:RGD	P	fatty acid catabolic process
GO:0007565	IEP:RGD	P	female pregnancy
GO:0042593	IEA:Ensembl	P	glucose homeostasis
GO:0006006	IEA:Ensembl	P	glucose metabolic process
GO:0006114	IDA:RGD	P	glycerol biosynthetic process
GO:0042445	IEA:Ensembl	P	hormone metabolic process
GO:0030073	IEA:Ensembl	P	insulin secretion
GO:0035556	IDA:RGD	P	intracellular signal transduction
GO:0007259	TAS:RGD	P	JAK-STAT cascade
GO:0033210	IDA:RGD	P	leptin-mediated signaling pathway
GO:0050901	IDA:RGD	P	leukocyte tethering or rolling
GO:0043066	IDA:RGD	P	negative regulation of apoptotic process
GO:0032099	ISS:HGNC	P	negative regulation of appetite
GO:0061037	IDA:RGD	P	negative regulation of cartilage development
GO:0070093	IEA:Ensembl	P	negative regulation of glucagon secretion
GO:2000486	IMP:RGD	P	negative regulation of glutamine transport
GO:0009892	IDA:RGD	P	negative regulation of metabolic process
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0045906	IDA:RGD	P	negative regulation of vasoconstriction
GO:0001542	IDA:RGD	P	ovulation from ovarian follicle
GO:0001890	IEA:Ensembl	P	placenta development
GO:0008284	IDA:RGD	P	positive regulation of cell proliferation
GO:0001819	IEP:RGD	P	positive regulation of cytokine production
GO:0048639	IEA:Ensembl	P	positive regulation of developmental growth
GO:0046881	IEP:RGD	P	positive regulation of follicle-stimulating hormone secretion
GO:2000491	IDA:RGD	P	positive regulation of hepatic stellate cell activation
GO:0046628	IDA:RGD	P	positive regulation of insulin receptor signaling pathway
GO:0043270	IDA:RGD	P	positive regulation of ion transport
GO:0046427	IMP:RGD	P	positive regulation of JAK-STAT cascade
GO:0033686	IEP:RGD	P	positive regulation of luteinizing hormone secretion
GO:0043410	IDA:RGD	P	positive regulation of MAPK cascade
GO:0045639	IEA:Ensembl	P	positive regulation of myeloid cell differentiation
GO:0035360	IDA:RGD	P	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:2000379	IDA:RGD	P	positive regulation of reactive oxygen species metabolic process
GO:2000366	IEA:Ensembl	P	positive regulation of STAT protein import into nucleus
GO:0042517	IMP:RGD	P	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0008217	IDA:RGD	P	regulation of blood pressure
GO:0045598	IEA:Ensembl	P	regulation of fat cell differentiation
GO:0006111	IEA:Ensembl	P	regulation of gluconeogenesis
GO:0050796	IEA:Ensembl	P	regulation of insulin secretion
GO:0030300	IEA:Ensembl	P	regulation of intestinal cholesterol absorption
GO:0060587	IDA:RGD	P	regulation of lipoprotein lipid oxidation
GO:0050810	IEA:Ensembl	P	regulation of steroid biosynthetic process
GO:0002021	IMP:RGD	P	response to dietary excess
GO:0001666	IEP:RGD	P	response to hypoxia
GO:0032868	IEA:Ensembl	P	response to insulin
GO:0007584	IEP:RGD	P	response to nutrient
GO:0033197	IEP:RGD	P	response to vitamin E
GO:0007260	IEA:Ensembl	P	tyrosine phosphorylation of STAT protein

KEGG Pathway Links

KEGG Pathway ID	Description
ko04920	Adipocytokine signaling pathway
rno04920	Adipocytokine signaling pathway
ko04152	AMPK signaling pathway
rno04152	AMPK signaling pathway
ko04060	Cytokine-cytokine receptor interaction
rno04060	Cytokine-cytokine receptor interaction
ko04630	Jak-STAT signaling pathway
rno04630	Jak-STAT signaling pathway
ko04080	Neuroactive ligand-receptor interaction
rno04080	Neuroactive ligand-receptor interaction
ko04932	Non-alcoholic fatty liver disease (NAFLD)
rno04932	Non-alcoholic fatty liver disease (NAFLD)

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953533	Developmental Biology
5954171	Incretin synthesis, secretion, and inactivation
5953345	Metabolism of proteins
5954094	Peptide hormone metabolism
5953543	Signaling by Leptin
5953381	Signal Transduction
5954252	Synthesis, secretion, and deacylation of Ghrelin
5954170	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
5954166	Transcriptional regulation of white adipocyte differentiation