LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012536

UniProt Annotations

Entry Information
Gene Nameacyl-CoA dehydrogenase, short/branched chain
Protein EntryACDSB_RAT
UniProt IDP70584
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron- transfer flavoprotein + H(+)
Catalytic ActivityAcyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
FunctionHas greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
SimilarityBelongs to the acyl-CoA dehydrogenase family
Subcellular LocationMitochondrion matrix .
SubunitHomotetramer
Tissue SpecificityUbiquitous.