LMPD Database

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LMP012538

UniProt Annotations

Entry Information
Gene Nameprostaglandin E receptor 1 (subtype EP1)
Protein EntryPE2R1_RAT
UniProt IDP70597
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70597-1; Sequence=Displayed; Name=2; IsoId=P70597-2; Sequence=VSP_001927, VSP_001928;
FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues
PtmPhosphorylated
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityHighly abundant in kidney and lung. Found in a lesser extent in spleen, colon, and thymus. Also expressed in uterine myometrium and endometrium.