LMPD Database

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LMP012543

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 3, group C, member 2
Protein EntryMCR_RAT
UniProt IDP22199
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P22199-1; Sequence=Displayed; Name=2; IsoId=P22199-2; Sequence=VSP_003705; Name=3; IsoId=P22199-3; Sequence=VSP_007361, VSP_007362; Note=Very low transactivation activity, not increased by aldosterone.;
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
PtmPhosphorylated
SimilarityBelongs to the nuclear hormone receptor family. NR3 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationCytoplasm . Nucleus . Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane (By similarity)
SubunitHeteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. Binds the coactivator NCOA2. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, TIF1 and NRIP1 (By similarity)
Tissue SpecificityDetected in liver, brain, heart, kidney, colon, aorta, hippocampus, hypothalamus and adrenal fasciculata