LMPD Database

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LMP012544

Gene Information

Entrez Gene ID25675
Gene Name3-hydroxy-3-methylglutaryl-CoA reductase
Gene SymbolHmgcr
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 IEA:InterProCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0043231 IDA:RGDCintracellular membrane-bounded organelle
GO:0005778 IEA:EnsemblCperoxisomal membrane
GO:0042282 IDA:RGDFhydroxymethylglutaryl-CoA reductase activity
GO:0004420 IEA:UniProtKB-ECFhydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0070402 IEA:EnsemblFNADPH binding
GO:0042803 IDA:RGDFprotein homodimerization activity
GO:0051721 IPI:RGDFprotein phosphatase 2A binding
GO:0007568 IEP:RGDPaging
GO:0006695 IDA:RGDPcholesterol biosynthetic process
GO:0015936 IEA:InterProPcoenzyme A metabolic process
GO:0010142 TAS:RGDPfarnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0008299 IDA:RGDPisoprenoid biosynthetic process
GO:0045445 IEP:RGDPmyoblast differentiation
GO:0043066 IMP:RGDPnegative regulation of apoptotic process
GO:0061179 IMP:RGDPnegative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043407 IEA:EnsemblPnegative regulation of MAP kinase activity
GO:0010664 IMP:RGDPnegative regulation of striated muscle cell apoptotic process
GO:0045908 IMP:RGDPnegative regulation of vasodilation
GO:0061045 IMP:RGDPnegative regulation of wound healing
GO:0010666 IMP:RGDPpositive regulation of cardiac muscle cell apoptotic process
GO:0008284 IMP:RGDPpositive regulation of cell proliferation
GO:0070374 IMP:RGDPpositive regulation of ERK1 and ERK2 cascade
GO:0048643 IMP:RGDPpositive regulation of skeletal muscle tissue development
GO:0048661 IMP:RGDPpositive regulation of smooth muscle cell proliferation
GO:0032874 IMP:RGDPpositive regulation of stress-activated MAPK cascade
GO:0051262 IEA:EnsemblPprotein tetramerization
GO:0045471 IEP:RGDPresponse to ethanol
GO:0007584 IEP:RGDPresponse to nutrient
GO:0006743 IMP:RGDPubiquinone metabolic process
GO:0008542 IEA:EnsemblPvisual learning
KEGG Pathway Links
KEGG Pathway IDDescription
ko04152AMPK signaling pathway
rno04152AMPK signaling pathway
ko04976Bile secretion
rno04976Bile secretion
M00095C5 isoprenoid biosynthesis, mevalonate pathway
rno01100Metabolic pathways
ko00900Terpenoid backbone biosynthesis
rno00900Terpenoid backbone biosynthesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
5954496Activation of gene expression by SREBF (SREBP)
5953924Cholesterol biosynthesis
5953288Fatty acid, triacylglycerol, and ketone body metabolism
5953250Metabolism
5953289Metabolism of lipids and lipoproteins
5954333PPARA activates gene expression
5954497Regulation of cholesterol biosynthesis by SREBP (SREBF)
5954222Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)