LMPD Database

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LMP012554

UniProt Annotations

Entry Information
Gene Nameacid phosphatase 5, tartrate resistant
Protein EntryPPA5_RAT
UniProt IDP29288
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA phosphate monoester + H(2)O = an alcohol + phosphate.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.;
FunctionMay play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.
Subcellular LocationLysosome.
SubunitExists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).
Tissue SpecificityCharacteristic constituent of osteoclasts and some mononuclear preosteoclasts. Preferentially expressed in skeletal tissues.