LMPD Database

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LMP012564

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 7
Protein EntryBACH_RAT
UniProt IDQ64559
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=2; Synonyms=LACH1, MTE-II; IsoId=Q64559-2; Sequence=Displayed; Name=1; Synonyms=BACH, CTE-IIa, CTE-II; IsoId=Q64559-1; Sequence=VSP_016956;
Biophysicochemical PropertiesKinetic parameters: KM=5.9 uM for palmitoyl-CoA; Vmax=553 umol/min/mg enzyme with palmitoyl-CoA as substrate;
Catalytic ActivityPalmitoyl-CoA + H(2)O = CoA + palmitate.
CautionThese proteins have been named according to their molecular weight (see PubMed:11755680): BACH (also called CTE-IIa and CTE-II), LACH1 (also called MTE-II) and ACT (also called CTE- IIb). It is unknown whether ACT corresponds to another isoform
DomainBoth hydrolase domains are required for efficient activity
FunctionAcyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18.
PtmThe N-terminus is blocked.
SimilarityContains 2 acyl coenzyme A hydrolase domains
Subcellular LocationCytoplasm.
SubunitHomohexamer
Tissue SpecificityIsoform 1 is expressed constitutively in brain and testis. Isoform 2 is induced in liver by treatment with the peroxisome proliferator.