LMPD Database

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LMP012569

UniProt Annotations

Entry Information
Gene Namearginase 1
Protein EntryARGI1_RAT
UniProt IDP07824
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=1.4 mM for arginine {ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:16266687};
Catalytic ActivityL-arginine + H(2)O = L-ornithine + urea.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00742, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:16266687}; Note=Binds 2 manganese ions per subunit. {ECO:0000255|PROSITE- ProRule:PRU00742, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:16266687};
Enzyme RegulationInactivated by diethyl pyrocarbonate (DEPC).
InductionBy arginine or homoarginine.
PathwayNitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
SimilarityBelongs to the arginase family. {ECO:0000255|PROSITE- ProRule:PRU00742}.
Subcellular LocationCytoplasm.
SubunitHomotrimer. {ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687}.
Tissue SpecificityDetected in liver (at protein level)