LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012572

UniProt Annotations

Entry Information
Gene Namesqualene epoxidase
Protein EntryERG1_RAT
UniProt IDP52020
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivitySqualene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionCatalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
SimilarityBelongs to the squalene monooxygenase family
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitMay form a complex with squalene synthase.