LMPD Database

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LMP012582

UniProt Annotations

Entry Information
Gene Namefatty acid amide hydrolase
Protein EntryFAAH1_RAT
UniProt IDP97612
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAnandamide + H(2)O = arachidonic acid + ethanolamine.
Catalytic ActivityOleamide + H(2)O = oleic acid + NH(3).
Developmental StageIn the CNS it accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postnatal day 30, then decreases into adulthood.
FunctionDegrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity)
SimilarityBelongs to the amidase family
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus membrane ; Single-pass membrane protein . Note=Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus.
SubunitHomodimer. {ECO:0000269|PubMed:12459591, ECO:0000269|PubMed:18753625}.
Tissue SpecificityFound in neuronal cells throughout the CNS. Expressed in liver and brain, and to a lesser extent in spleen, lung, kidney and testes