LMPD Database

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LMP012592

UniProt Annotations

Entry Information
Gene NameP450 (cytochrome) oxidoreductase
Protein EntryNCPR_RAT
UniProt IDP00388
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityNADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
CofactorName=FMN; Xref=ChEBI:CHEBI:58210;
FunctionThis enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
SimilarityContains 1 FAD-binding FR-type domain
SimilarityContains 1 flavodoxin-like domain
SimilarityIn the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Note=Anchored to the ER membrane by its N- terminal hydrophobic region.