LMPD Database

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LMP012598

Gene Information

Entrez Gene ID29499
Gene Namesonic hedgehog
Gene SymbolShh
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IDA:RGDCaxon
GO:0009986 ISS:UniProtKBCcell surface
GO:0030425 IDA:RGDCdendrite
GO:0005783 IDA:RGDCendoplasmic reticulum
GO:0005615 ISS:UniProtKBCextracellular space
GO:0005794 IDA:RGDCGolgi apparatus
GO:0045121 ISS:UniProtKBCmembrane raft
GO:0043025 IDA:RGDCneuronal cell body
GO:0005886 IEA:UniProtKB-KWCplasma membrane
GO:0030133 IDA:RGDCtransport vesicle
GO:0005509 ISS:UniProtKBFcalcium ion binding
GO:0043237 ISS:UniProtKBFlaminin-1 binding
GO:0008233 IEA:UniProtKB-KWFpeptidase activity
GO:0005102 TAS:RGDFreceptor binding
GO:0008270 ISS:UniProtKBFzinc ion binding
GO:0008209 ISS:UniProtKBPandrogen metabolic process
GO:0097190 ISS:UniProtPapoptotic signaling pathway
GO:0007411 ISS:UniProtKBPaxon guidance
GO:0001658 ISS:UniProtKBPbranching involved in ureteric bud morphogenesis
GO:0048754 ISS:UniProtKBPbranching morphogenesis of an epithelial tube
GO:0043369 ISS:UniProtKBPCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0007267 ISS:UniProtKBPcell-cell signaling
GO:0048468 ISS:UniProtKBPcell development
GO:0001708 ISS:UniProtKBPcell fate specification
GO:0007417 ISS:UniProtKBPcentral nervous system development
GO:0021930 ISS:UniProtKBPcerebellar granule cell precursor proliferation
GO:0007502 IDA:RGDPdigestive tract mesoderm development
GO:0009953 ISS:UniProtKBPdorsal/ventral pattern formation
GO:0009790 ISS:UniProtKBPembryo development
GO:0042733 ISS:UniProtKBPembryonic digit morphogenesis
GO:0030326 ISS:UniProtKBPembryonic limb morphogenesis
GO:0060441 IEP:RGDPepithelial tube branching involved in lung morphogenesis
GO:0030900 ISS:UniProtKBPforebrain development
GO:0061196 IMP:RGDPfungiform papilla development
GO:0061198 IMP:RGDPfungiform papilla formation
GO:0061197 IMP:RGDPfungiform papilla morphogenesis
GO:0007507 ISS:UniProtKBPheart development
GO:0030902 ISS:UniProtKBPhindbrain development
GO:0016539 IEA:InterProPintein-mediated protein splicing
GO:0030324 ISS:UniProtKBPlung development
GO:0002320 ISS:UniProtKBPlymphoid progenitor cell differentiation
GO:0030539 ISS:UniProtKBPmale genitalia development
GO:0048808 IMP:RGDPmale genitalia morphogenesis
GO:0072136 ISS:UniProtKBPmetanephric mesenchymal cell proliferation involved in metanephros development
GO:0001656 ISS:UniProtKBPmetanephros development
GO:0030901 ISS:UniProtKBPmidbrain development
GO:0043066 IMP:RGDPnegative regulation of apoptotic process
GO:0045596 ISS:UniProtKBPnegative regulation of cell differentiation
GO:0030336 ISS:UniProtKBPnegative regulation of cell migration
GO:2000357 ISS:UniProtKBPnegative regulation of kidney smooth muscle cell differentiation
GO:2000062 ISS:UniProtKBPnegative regulation of ureter smooth muscle cell differentiation
GO:0045060 ISS:UniProtKBPnegative thymic T cell selection
GO:0001755 ISS:UniProtKBPneural crest cell migration
GO:0001841 IMP:RGDPneural tube formation
GO:0007405 ISS:UniProtKBPneuroblast proliferation
GO:0048663 ISS:UniProtKBPneuron fate commitment
GO:0001569 ISS:UniProtKBPpatterning of blood vessels
GO:0007389 ISS:UniProtKBPpattern specification process
GO:0009949 ISS:UniProtPpolarity specification of anterior/posterior axis
GO:0046638 ISS:UniProtKBPpositive regulation of alpha-beta T cell differentiation
GO:0008284 ISS:UniProtKBPpositive regulation of cell proliferation
GO:0033092 ISS:UniProtKBPpositive regulation of immature T cell proliferation in thymus
GO:2000358 ISS:UniProtKBPpositive regulation of kidney smooth muscle cell differentiation
GO:2000729 ISS:UniProtKBPpositive regulation of mesenchymal cell proliferation involved in ureter development
GO:0002052 IDA:RGDPpositive regulation of neuroblast proliferation
GO:0045666 IMP:RGDPpositive regulation of neuron differentiation
GO:0070447 IDA:RGDPpositive regulation of oligodendrocyte progenitor proliferation
GO:0060406 IMP:RGDPpositive regulation of penile erection
GO:0046534 IDA:RGDPpositive regulation of photoreceptor cell differentiation
GO:0045880 ISS:UniProtKBPpositive regulation of smoothened signaling pathway
GO:0033089 ISS:UniProtKBPpositive regulation of T cell differentiation in thymus
GO:0045893 ISS:UniProtKBPpositive regulation of transcription, DNA-templated
GO:2000063 ISS:UniProtKBPpositive regulation of ureter smooth muscle cell differentiation
GO:0045059 ISS:UniProtKBPpositive thymic T cell selection
GO:0030850 ISS:UniProtKBPprostate gland development
GO:0042127 ISS:UniProtKBPregulation of cell proliferation
GO:0030856 IEP:RGDPregulation of epithelial cell differentiation
GO:0030162 ISS:UniProtKBPregulation of proteolysis
GO:0048678 IMP:RGDPresponse to axon injury
GO:0032355 IEP:RGDPresponse to estradiol
GO:0045471 IDA:RGDPresponse to ethanol
GO:0001666 IEP:RGDPresponse to hypoxia
GO:0010243 IEP:RGDPresponse to organonitrogen compound
GO:0032526 IEP:RGDPresponse to retinoic acid
GO:0007224 ISS:UniProtKBPsmoothened signaling pathway
GO:0021513 IDA:MGIPspinal cord dorsal/ventral patterning
GO:0048864 ISS:UniProtKBPstem cell development
GO:0033077 ISS:UniProtKBPT cell differentiation in thymus
GO:0021978 IMP:RGDPtelencephalon regionalization
GO:0048538 ISS:UniProtKBPthymus development
GO:0043586 IMP:RGDPtongue development
GO:0043587 IMP:RGDPtongue morphogenesis
GO:0001570 ISS:UniProtKBPvasculogenesis
GO:0021521 IDA:MGIPventral spinal cord interneuron specification
KEGG Pathway Links
KEGG Pathway IDDescription
ko05217Basal cell carcinoma
rno05217Basal cell carcinoma
ko04340Hedgehog signaling pathway
rno04340Hedgehog signaling pathway
rno05200Pathways in cancer
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953757Class B/2 (Secretin family receptors)
5953253Disease
5953758GPCR ligand binding
5954643Hedgehog ligand biogenesis
5954646Hh ligand biogenesis disease
5954645Processing-defective Hh variants abrogate ligand secretion
5954650Release of Hh-Np from the secreting cell
5953391Signaling by GPCR
5954644Signaling by Hedgehog
5953381Signal Transduction