LMPD Database

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LMP012603

Gene Information

Entrez Gene ID29527
Gene Nameprostaglandin-endoperoxide synthase 2
Gene SymbolPtgs2
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005783 IEA:UniProtKB-KWCendoplasmic reticulum
GO:0016020 IEA:UniProtKB-KWCmembrane
GO:0043005 IEA:EnsemblCneuron projection
GO:0005634 ISS:UniProtKBCnucleus
GO:0043234 IDA:RGDCprotein complex
GO:0020037 ISS:UniProtKBFheme binding
GO:0008289 IMP:RGDFlipid binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0016702 IDA:RGDFoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0004601 IEA:UniProtKB-KWFperoxidase activity
GO:0004666 ISS:UniProtKBFprostaglandin-endoperoxide synthase activity
GO:0042640 IEA:EnsemblPanagen
GO:0001525 IMP:RGDPangiogenesis
GO:0030282 IMP:MGIPbone mineralization
GO:0050873 IEA:EnsemblPbrown fat cell differentiation
GO:0071318 IEP:RGDPcellular response to ATP
GO:0071456 IEA:EnsemblPcellular response to hypoxia
GO:0071260 IEP:RGDPcellular response to mechanical stimulus
GO:0034644 IEP:RGDPcellular response to UV
GO:0019371 ISS:UniProtKBPcyclooxygenase pathway
GO:0046697 IMP:RGDPdecidualization
GO:0007566 IMP:RGDPembryo implantation
GO:0042633 IEP:RGDPhair cycle
GO:0006954 IMP:RGDPinflammatory response
GO:0007612 IMP:RGDPlearning
GO:0035633 IMP:RGDPmaintenance of blood-brain barrier
GO:0007613 IMP:RGDPmemory
GO:0051926 IMP:RGDPnegative regulation of calcium ion transport
GO:0045786 IGI:RGDPnegative regulation of cell cycle
GO:0008285 IDA:RGDPnegative regulation of cell proliferation
GO:0045986 IMP:RGDPnegative regulation of smooth muscle contraction
GO:0032227 IMP:RGDPnegative regulation of synaptic transmission, dopaminergic
GO:0030728 IMP:RGDPovulation
GO:0043065 IMP:RGDPpositive regulation of apoptotic process
GO:0090336 IEA:EnsemblPpositive regulation of brown fat cell differentiation
GO:0010942 IMP:RGDPpositive regulation of cell death
GO:0090050 IMP:BHF-UCLPpositive regulation of cell migration involved in sprouting angiogenesis
GO:0008284 IMP:RGDPpositive regulation of cell proliferation
GO:0031622 IDA:BHF-UCLPpositive regulation of fever generation
GO:0090271 IMP:BHF-UCLPpositive regulation of fibroblast growth factor production
GO:0042346 IMP:RGDPpositive regulation of NF-kappaB import into nucleus
GO:0045429 IMP:BHF-UCLPpositive regulation of nitric oxide biosynthetic process
GO:0090362 IMP:BHF-UCLPpositive regulation of platelet-derived growth factor production
GO:0048661 IMP:RGDPpositive regulation of smooth muscle cell proliferation
GO:0045987 IMP:RGDPpositive regulation of smooth muscle contraction
GO:0031915 IMP:RGDPpositive regulation of synaptic plasticity
GO:0051968 IMP:RGDPpositive regulation of synaptic transmission, glutamatergic
GO:0071636 IMP:BHF-UCLPpositive regulation of transforming growth factor beta production
GO:0045907 IMP:RGDPpositive regulation of vasoconstriction
GO:0010575 IMP:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0001516 IMP:RGDPprostaglandin biosynthetic process
GO:0008217 ISS:UniProtKBPregulation of blood pressure
GO:0034097 IMP:RGDPresponse to cytokine
GO:0042493 IEP:RGDPresponse to drug
GO:0032355 IEP:RGDPresponse to estradiol
GO:0070542 IEP:RGDPresponse to fatty acid
GO:0009750 IEP:RGDPresponse to fructose
GO:0051384 IEP:RGDPresponse to glucocorticoid
GO:0032496 IMP:RGDPresponse to lipopolysaccharide
GO:0010226 IEP:RGDPresponse to lithium ion
GO:0010042 IEP:RGDPresponse to manganese ion
GO:0014070 IEP:RGDPresponse to organic cyclic compound
GO:0010033 IEP:RGDPresponse to organic substance
GO:0010243 IEP:RGDPresponse to organonitrogen compound
GO:0006979 IEA:InterProPresponse to oxidative stress
GO:0009314 IEP:RGDPresponse to radiation
GO:0034612 IEP:RGDPresponse to tumor necrosis factor
GO:0033280 IEP:RGDPresponse to vitamin D
GO:0019233 IMP:RGDPsensory perception of pain
KEGG Pathway Links
KEGG Pathway IDDescription
ko00590Arachidonic acid metabolism
rno00590Arachidonic acid metabolism
ko05204Chemical carcinogenesis
rno05204Chemical carcinogenesis
ko05140Leishmaniasis
rno05140Leishmaniasis
rno01100Metabolic pathways
ko05206MicroRNAs in cancer
rno05206MicroRNAs in cancer
rno04064NF-kappa B signaling pathway
ko04913Ovarian steroidogenesis
rno04913Ovarian steroidogenesis
ko04921Oxytocin signaling pathway
rno04921Oxytocin signaling pathway
rno05200Pathways in cancer
ko04723Retrograde endocannabinoid signaling
rno04723Retrograde endocannabinoid signaling
rno04726Serotonergic synapse
ko05222Small cell lung cancer
rno05222Small cell lung cancer
ko04668TNF signaling pathway
rno04668TNF signaling pathway
ko04370VEGF signaling pathway
rno04370VEGF signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953493Arachidonic acid metabolism
5953298Defective AMN causes hereditary megaloblastic anemia 1
5953308Defective BTD causes biotidinase deficiency
5953307Defective CD320 causes methylmalonic aciduria
5953299Defective CUBN causes hereditary megaloblastic anemia 1
5953296Defective GIF causes intrinsic factor deficiency
5953310Defective HLCS causes multiple carboxylase deficiency
5953297Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
5953305Defective MMAA causes methylmalonic aciduria type cblA
5953302Defective MMAB causes methylmalonic aciduria type cblB
5953304Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
5953303Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
5953301Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
5953300Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
5953306Defective MUT causes methylmalonic aciduria mut type
5953293Defective TCN2 causes hereditary megaloblastic anemia
5953309Defects in biotin (Btn) metabolism
5953294Defects in cobalamin (B12) metabolism
5953295Defects in vitamin and cofactor metabolism
5953253Disease
5953250Metabolism
5953289Metabolism of lipids and lipoproteins
5953292Metabolism of vitamins and cofactors
5953291Metabolism of water-soluble vitamins and cofactors
5953489Nicotinamide salvaging
5953490Nicotinate metabolism
5954557Synthesis of 15-eicosatetraenoic acid derivatives
5953492Synthesis of Prostaglandins (PG) and Thromboxanes (TX)