LMPD Database

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LMP012606

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 7
Protein EntryDHB7_RAT
UniProt IDQ62904
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityA 3-beta-hydroxysteroid + NADP(+) = a 3- oxosteroid + NADPH.
FunctionResponsible for the reduction of the keto group on the C-3 of sterols.
PathwaySteroid biosynthesis; estrogen biosynthesis.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
PtmPhosphorylated.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily
Subcellular LocationCell membrane; Single-pass membrane protein.
SubunitBinds to the short form of prolactin receptor.
Tissue SpecificityMost abundant in ovaries of pregnant animals.