LMPD Database

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LMP012609

UniProt Annotations

Entry Information
Gene Namecellular retinoic acid binding protein 2
Protein EntryRABP2_RAT
UniProt IDP51673
SpeciesRat
Comments
Comment typeDescription
DomainForms a beta-barrel structure that accommodates hydrophobic ligands in its interior
FunctionTransports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity)
PtmSumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
SimilarityBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family
Subcellular LocationCytoplasm. Endoplasmic reticulum {ECO:0000250}. Nucleus . Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus
SubunitInteracts with importin alpha, RXR and RARA