LMPD Database

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LMP012617

UniProt Annotations

Entry Information
Gene Namearachidonate 5-lipoxygenase activating protein
Protein EntryAL5AP_RAT
UniProt IDP20291
SpeciesRat
Comments
Comment typeDescription
DomainThe C-terminal part after residue 140 is mostly disordered
FunctionRequired for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. unstructured (By similarity)
SimilarityBelongs to the MAPEG family
Subcellular LocationNucleus membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
SubunitHomotrimer. Interacts with LTC4S and ALOX5 (By similarity)