LMPD Database

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LMP012618

UniProt Annotations

Entry Information
Gene Namehydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
Protein Entry3BHS4_RAT
UniProt IDQ62878
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.
Catalytic ActivityA 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)- steroid.
Function3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
PathwayLipid metabolism; steroid biosynthesis.
SimilarityBelongs to the 3-beta-HSD family
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue SpecificitySkin, placenta, also detectable in ovary and adrenal gland.