LMPD Database

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LMP012620

UniProt Annotations

Entry Information
Gene Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Protein EntryDPM2_RAT
UniProt IDQ9Z325
SpeciesRat
Comments
Comment typeDescription
FunctionRegulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity
InteractionQ9P2X0:DPM3 (xeno); NbExp=2; IntAct=EBI-9097185, EBI-9087337;
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the DPM2 family
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
SubunitComponent of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex