LMPD Database

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LMP012637

UniProt Annotations

Entry Information
Gene NameUDP glycosyltransferase 8
Protein EntryCGT_RAT
UniProt IDQ09426
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + 2-(2- hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2- hydroxyacyl)sphingosine.
FunctionCatalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
PathwaySphingolipid metabolism; galactosylceramide biosynthesis.
SimilarityBelongs to the UDP-glycosyltransferase family
Subcellular LocationMembrane ; Single-pass membrane protein .
Tissue SpecificityBrain, restricted to the oligodendrocyte- containing cell layers of cerebrum and cerebellum.