LMPD Database

LMP012638

Gene Information

Entrez Gene ID	50557
Gene Name	phosphatase and tensin homolog
Gene Symbol	Pten
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:RGD	C	cytoplasm
GO:0009898	IEA:Ensembl	C	cytoplasmic side of plasma membrane
GO:0043197	IDA:RGD	C	dendritic spine
GO:0005739	IDA:RGD	C	mitochondrion
GO:0035749	IEA:Ensembl	C	myelin sheath adaxonal region
GO:0043005	IDA:RGD	C	neuron projection
GO:0005634	IDA:RGD	C	nucleus
GO:0045211	IDA:RGD	C	postsynaptic membrane
GO:0043220	IEA:Ensembl	C	Schmidt-Lanterman incisure
GO:0051717	IEA:Ensembl	F	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0030165	IPI:RGD	F	PDZ domain binding
GO:0016314	IDA:RGD	F	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800	IEA:InterPro	F	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438	IEA:Ensembl	F	phosphatidylinositol-3-phosphatase activity
GO:0005161	IDA:RGD	F	platelet-derived growth factor receptor binding
GO:0004722	IEA:Ensembl	F	protein serine/threonine phosphatase activity
GO:0004725	IEA:InterPro	F	protein tyrosine phosphatase activity
GO:0008138	TAS:RGD	F	protein tyrosine/serine/threonine phosphatase activity
GO:0007092	IEA:Ensembl	P	activation of mitotic anaphase-promoting complex activity
GO:0007568	IEP:RGD	P	aging
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0060070	IEA:Ensembl	P	canonical Wnt signaling pathway
GO:0048738	IEA:Ensembl	P	cardiac muscle tissue development
GO:0032286	IEA:Ensembl	P	central nervous system myelin maintenance
GO:0021955	IEA:Ensembl	P	central nervous system neuron axonogenesis
GO:0060997	IEA:Ensembl	P	dendritic spine morphogenesis
GO:0021542	IEA:Ensembl	P	dentate gyrus development
GO:0043542	IEA:Ensembl	P	endothelial cell migration
GO:0048853	IEA:Ensembl	P	forebrain morphogenesis
GO:0046855	IEA:InterPro	P	inositol phosphate dephosphorylation
GO:0045475	IEA:Ensembl	P	locomotor rhythm
GO:0060292	IMP:RGD	P	long term synaptic depression
GO:0060291	IEA:Ensembl	P	long-term synaptic potentiation
GO:0060179	IEA:Ensembl	P	male mating behavior
GO:0042711	IEA:Ensembl	P	maternal behavior
GO:0007613	IMP:RGD	P	memory
GO:0033555	IEA:Ensembl	P	multicellular organismal response to stress
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0050771	IEA:Ensembl	P	negative regulation of axonogenesis
GO:0090344	IEA:Ensembl	P	negative regulation of cell aging
GO:0030336	IEA:InterPro	P	negative regulation of cell migration
GO:0008285	IDA:RGD	P	negative regulation of cell proliferation
GO:0045792	IEA:Ensembl	P	negative regulation of cell size
GO:0031658	IEA:Ensembl	P	negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0061002	IEA:Ensembl	P	negative regulation of dendritic spine morphogenesis
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0090394	IEA:Ensembl	P	negative regulation of excitatory postsynaptic membrane potential
GO:0051895	IEA:InterPro	P	negative regulation of focal adhesion assembly
GO:2000134	IEA:Ensembl	P	negative regulation of G1/S transition of mitotic cell cycle
GO:0031642	IEA:Ensembl	P	negative regulation of myelination
GO:0046621	IEA:Ensembl	P	negative regulation of organ growth
GO:0050765	IMP:RGD	P	negative regulation of phagocytosis
GO:0051898	IEA:Ensembl	P	negative regulation of protein kinase B signaling
GO:0090071	IEA:Ensembl	P	negative regulation of ribosome biogenesis
GO:2000808	IEA:Ensembl	P	negative regulation of synaptic vesicle clustering
GO:0007270	IEA:Ensembl	P	neuron-neuron synaptic transmission
GO:0031175	IDA:RGD	P	neuron projection development
GO:0046856	IMP:RGD	P	phosphatidylinositol dephosphorylation
GO:0048008	IDA:RGD	P	platelet-derived growth factor receptor signaling pathway
GO:0043065	IMP:RGD	P	positive regulation of apoptotic process
GO:2001235	IEA:Ensembl	P	positive regulation of apoptotic signaling pathway
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:2000463	IEA:Ensembl	P	positive regulation of excitatory postsynaptic membrane potential
GO:2000060	IEA:Ensembl	P	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091	IEA:Ensembl	P	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107	IEA:Ensembl	P	postsynaptic density assembly
GO:0060134	IEA:Ensembl	P	prepulse inhibition
GO:0097105	IEA:Ensembl	P	presynaptic membrane assembly
GO:0060736	IEA:Ensembl	P	prostate gland growth
GO:0043491	IEA:Ensembl	P	protein kinase B signaling
GO:0050821	IEA:Ensembl	P	protein stabilization
GO:0002902	IEA:Ensembl	P	regulation of B cell apoptotic process
GO:0033032	IEA:Ensembl	P	regulation of myeloid cell apoptotic process
GO:0046685	IEP:RGD	P	response to arsenic-containing substance
GO:0033198	IEP:RGD	P	response to ATP
GO:0042493	IEP:RGD	P	response to drug
GO:0032355	IEP:RGD	P	response to estradiol
GO:0045471	IEP:RGD	P	response to ethanol
GO:0009749	IEP:RGD	P	response to glucose
GO:0010035	IEP:RGD	P	response to inorganic substance
GO:0007584	IEP:RGD	P	response to nutrient
GO:0014070	IEP:RGD	P	response to organic cyclic compound
GO:0010033	IEP:RGD	P	response to organic substance
GO:0010043	IEP:RGD	P	response to zinc ion
GO:0060024	IEA:Ensembl	P	rhythmic synaptic transmission
GO:0035176	IEA:Ensembl	P	social behavior
GO:0060074	IEA:Ensembl	P	synapse maturation

KEGG Pathway Links

KEGG Pathway ID	Description
ko05213	Endometrial cancer
rno05213	Endometrial cancer
ko04510	Focal adhesion
rno04510	Focal adhesion
rno04068	FoxO signaling pathway
ko05214	Glioma
rno05214	Glioma
rno05161	Hepatitis B
ko00562	Inositol phosphate metabolism
rno00562	Inositol phosphate metabolism
ko05218	Melanoma
rno05218	Melanoma
ko05206	MicroRNAs in cancer
rno05206	MicroRNAs in cancer
ko04150	mTOR signaling pathway
rno04150	mTOR signaling pathway
ko04115	p53 signaling pathway
rno04115	p53 signaling pathway
rno05200	Pathways in cancer
ko04070	Phosphatidylinositol signaling system
rno04070	Phosphatidylinositol signaling system
ko04151	PI3K-Akt signaling pathway
rno04151	PI3K-Akt signaling pathway
ko05215	Prostate cancer
rno05215	Prostate cancer
ko05222	Small cell lung cancer
rno05222	Small cell lung cancer
ko04530	Tight junction
rno04530	Tight junction

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953415	Adaptive Immune System
5954570	Constitutive PI3K/AKT Signaling in Cancer
5953408	DAP12 interactions
5953407	DAP12 signaling
5953253	Disease
5953994	Downstream signaling events of B Cell Receptor (BCR)
5953399	Downstream signaling of activated FGFR
5953396	Downstream signal transduction
5954035	Downstream TCR signaling
5953417	Fc epsilon receptor (FCERI) signaling
5953884	GAB1 signalosome
5953410	Immune System
5953409	Innate Immune System
5954515	Inositol phosphate metabolism
5953250	Metabolism
5953289	Metabolism of lipids and lipoproteins
5954013	Negative regulation of the PI3K/AKT network
5953394	NGF signalling via TRKA from the plasma membrane
5953474	Phospholipid metabolism
5953989	PI3K/AKT activation
5953997	PI3K/AKT Signaling in Cancer
5953885	PI-3K cascade
5953996	PI3K events in ERBB2 signaling
5953995	PI3K events in ERBB4 signaling
5954478	PI Metabolism
5953993	PIP3 activates AKT signaling
5953998	Role of LAT2/NTAL/LAB on calcium mobilization
5953403	Signaling by EGFR
5953404	Signaling by EGFR in Cancer
5953406	Signaling by ERBB2
5953540	Signaling by ERBB4
5953400	Signaling by FGFR
5953401	Signaling by FGFR in disease
5953397	Signaling by PDGF
5953541	Signaling by SCF-KIT
5953414	Signaling by the B Cell Receptor (BCR)
5953395	Signalling by NGF
5953381	Signal Transduction
5954514	Synthesis of IP3 and IP4 in the cytosol
5954499	Synthesis of PIPs at the plasma membrane
5954036	TCR signaling