LMPD Database

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LMP012643

UniProt Annotations

Entry Information
Gene Nameacyl-CoA oxidase 1, palmitoyl
Protein EntryACOX1_RAT
UniProt IDP07872
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ACO-I; IsoId=P07872-1; Sequence=Displayed; Name=2; Synonyms=ACO-II; IsoId=P07872-2; Sequence=VSP_000147;
Catalytic ActivityAcyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionCatalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 1 shows optimum activity with a chain length of 10 carbons while isoform 2 exhibits optimum activity with 14 carbons
PathwayLipid metabolism; peroxisomal fatty acid beta-oxidation.
SimilarityBelongs to the acyl-CoA oxidase family
Subcellular LocationPeroxisome.
SubunitHomodimer. The enzyme contains three components A, B and C, the latter two being produced from the first by a proteolytic cleavage. {ECO:0000269|PubMed:11872165, ECO:0000269|PubMed:16672280}.