LMPD Database

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LMP012645

UniProt Annotations

Entry Information
Gene Nameapolipoprotein B
Protein EntryAPOB_RAT
UniProt IDQ7TMA5
SpeciesRat
Comments
Comment typeDescription
FunctionApolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor
PtmPalmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle
Rna EditingModified_positions=2147 ; Note=The stop codon (UAA) at position 2147 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL.;
SimilarityContains 1 vitellogenin domain. {ECO:0000255|PROSITE- ProRule:PRU00557}.
Subcellular LocationCytoplasm . Secreted .
SubunitInteracts with PCSK9
Tissue SpecificityDetected in intestine and liver (at protein level)