LMPD Database

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LMP012650

UniProt Annotations

Entry Information
Gene Namenuclear receptor co-repressor 1
Protein Entry
UniProt ID
SpeciesRat
Comments
Comment typeDescription
DomainThe C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity). {ECO:0000250}.
DomainThe N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3). {ECO:0000250}.
FunctionMediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6 (By similarity). {ECO:0000250}.
PtmUbiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000250}.
SimilarityBelongs to the N-CoR nuclear receptor corepressors family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitForms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA (By similarity). {ECO:0000250}.