LMPD Database

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LMP012660

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 0, group B, member 1
Protein EntryNR0B1_RAT
UniProt IDP70503
SpeciesRat
Comments
Comment typeDescription
DomainHomodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N- terminal LXXLL motifs (By similarity)
FunctionOrphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity)
SimilarityBelongs to the nuclear hormone receptor family. NR0 subfamily
Subcellular LocationNucleus . Cytoplasm . Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity)
SubunitHomodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity)