LMPD Database

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LMP012661

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group H, member 2
Protein EntryNR1H2_RAT
UniProt IDQ62755
SpeciesRat
Comments
Comment typeDescription
FunctionNuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity)
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitForms a heterodimer with RXR.