LMPD Database

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LMP012679

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Protein EntryP55G_RAT
UniProt IDQ63789
SpeciesRat
Comments
Comment typeDescription
FunctionBinds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
SimilarityBelongs to the PI3K p85 subunit family
SimilarityContains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SubunitHeterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL (By similarity)
Tissue SpecificityHighest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.