LMPD Database

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LMP012689

UniProt Annotations

Entry Information
Gene Namelecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Protein EntryLRAT_RAT
UniProt IDQ9JI61
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + retinol--[cellular- retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl- ester--[cellular-retinol-binding-protein].
Enzyme RegulationInhibited by all-trans-retinyl alpha- bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK)
FunctionTransfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11- cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments
InductionLRAT activity is up-regulated by dietary vitamin A. Under conditions of vitamin A depletion, LRAT expression in the liver is induced by retinoic acid. {ECO:0000269|PubMed:11108736, ECO:0000269|PubMed:1885578}.
PathwayCofactor metabolism; retinol metabolism.
SimilarityBelongs to the H-rev107 family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein . Rough endoplasmic reticulum . Endosome, multivesicular body . Cytoplasm, perinuclear region . Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells.
Tissue SpecificityHepatic stellate cells and endothelial cells (at protein level). Highly expressed in adrenal gland, small intestine, testis and eye. Lower levels of expression are observed in liver, heart, lung, skin, mammary tissue and skeletal muscle