LMPD Database

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LMP012691

UniProt Annotations

Entry Information
Gene Nameplatelet-activating factor acetylhydrolase 1b, catalytic subunit 2
Protein EntryPA1B2_RAT
UniProt IDO35264
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
FunctionInactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit.
InteractionP43033:PAFAH1B1 (xeno); NbExp=2; IntAct=EBI-915500, EBI-1007886;
SimilarityBelongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
SimilarityBelongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm .
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitCytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.
Tissue SpecificityExpressed in heart, brain, spleen, lung, liver, kidney and testis. Not expressed in skeletal muscle.