LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012705

UniProt Annotations

Entry Information
Gene Name3'(2'), 5'-bisphosphate nucleotidase 1
Protein EntryBPNT1_RAT
UniProt IDQ9Z1N4
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAdenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationUncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4- bisphosphate. Inhibited by calcium ions
FunctionConverts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6
SimilarityBelongs to the inositol monophosphatase family
Tissue SpecificityHighly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis