LMPD Database

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LMP012707

UniProt Annotations

Entry Information
Gene Namefarnesyltransferase, CAAX box, beta
Protein EntryFNTB_RAT
UniProt IDQ02293
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:22963166}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427};
FunctionEssential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:22963166}.
InteractionQ04631:Fnta; NbExp=14; IntAct=EBI-602454, EBI-602447;
SimilarityBelongs to the protein prenyltransferase subunit beta family
SimilarityContains 5 PFTB repeats
SubunitHeterodimer of FNTA and FNTB. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9065406, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}.