LMPD Database

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LMP012716

UniProt Annotations

Entry Information
Gene Namesteroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Protein EntryS5A2_RAT
UniProt IDP31214
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=74 nM for testosterone ; KM=42 nM for progesterone ; KM=170 nM for androstenedione ; KM=376 nM for corticosterone ; KM=11.2 uM for cortisol ; Vmax=0.5 nmol/min/mg enzyme ; pH dependence: Optimally active at acidic pHs. ;
Catalytic ActivityA 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH
FunctionConverts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity)
SimilarityBelongs to the steroid 5-alpha reductase family
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed in high levels in the prostate and many other androgen-sensitive tissues