LMPD Database

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LMP012718

UniProt Annotations

Entry Information
Gene Namebeta-1,4-N-acetyl-galactosaminyl transferase 1
Protein EntryB4GN1_RAT
UniProt IDQ10468
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-alpha-D-galactosamine + O-(N- acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)- beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)- 2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha- neuraminyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D- glucopyranosyl-(1<->1)-ceramide.
FunctionInvolved in the biosynthesis of gangliosides GM2, GD2 and asialo-GM2.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 2 family
Subcellular LocationGolgi apparatus membrane; Single-pass type II membrane protein.
SubunitHomodimer; disulfide-linked
Tissue SpecificityStrongly expressed in brain, testis, spleen, and to a lesser extent in liver.