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LMPD Database

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LMP012726

UniProt Annotations

Entry Information

Gene Name	phosphatidylinositol 3-kinase, catalytic subunit type 3
Protein Entry	PK3C3_RAT
UniProt ID	O88763
Species	Rat

Comments

Comment type	Description
Catalytic Activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Function	Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes (By similarity)
Similarity	Belongs to the PI3/PI4-kinase family
Similarity	Contains 1 C2 PI3K-type domain. {ECO:0000255\|PROSITE- ProRule:PRU00880}.
Similarity	Contains 1 PI3K/PI4K domain. {ECO:0000255\|PROSITE- ProRule:PRU00269}.
Similarity	Contains 1 PIK helical domain. {ECO:0000255\|PROSITE- ProRule:PRU00878}.
Subcellular Location	Midbody . Late endosome . Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme
Subunit	Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Interacts with AMBRA1 (By similarity). Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive (By similarity). Part of a complex composed of PIK3R4 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3R4. Interacts with BECN1P1/BECN2 (By similarity)