LMPD Database

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LMP012738

UniProt Annotations

Entry Information
Gene Namesolute carrier family 27 (fatty acid transporter), member 5
Protein EntryS27A5_RAT
UniProt IDQ9ES38
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + (25R)-3-alpha,7-alpha,12-alpha- trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA
Catalytic ActivityATP + cholate + CoA = AMP + diphosphate + choloyl-CoA
FunctionAcyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Tissue SpecificityPredominantly expressed in liver (at protein level)