LMPD Database

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LMP012748

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 2
Protein EntryDHB2_RAT
UniProt IDQ62730
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityTestosterone + NAD(+) = androstenedione + NADH.
FunctionCapable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Favors the oxidation of estradiol and testosterone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity)
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationMembrane ; Single-pass type II membrane protein .
Tissue SpecificityHighest expression in placenta.