LMPD Database

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LMP012765

UniProt Annotations

Entry Information
Gene Namemevalonate kinase
Protein EntryKIME_RAT
UniProt IDP17256
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate.
DiseaseNote=Mutation in the mevalonate kinase gene causes mevalonicaciduria.
Enzyme RegulationFarnesyl- and geranyl-pyrophosphates are competitive inhibitors.
FunctionMay be a regulatory site in cholesterol biosynthetic pathway.
MiscellaneousThe authors of PubMed:14730012 identify two forms of Mvk in rat liver, one form localizes to the cytosol and the other form to the peroxisome, whereas according to the authors of PubMed:14730012 the protein is found only in the cytoplasm with no evidence for its peroxisomal localization.
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
SimilarityBelongs to the GHMP kinase family. Mevalonate kinase subfamily
Subcellular LocationCytoplasm. Peroxisome.
SubunitHomodimer