LMPD Database

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LMP012767

Gene Information

Entrez Gene ID81745
Gene Name3-phosphoinositide dependent protein kinase-1
Gene SymbolPdpk1
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0042995 IEA:EnsemblCcell projection
GO:0016023 IEA:EnsemblCcytoplasmic membrane-bounded vesicle
GO:0005829 IDA:RGDCcytosol
GO:0005634 IEA:UniProtKB-KWCnucleus
GO:0005886 IDA:RGDCplasma membrane
GO:0004676 IDA:RGDF3-phosphoinositide-dependent protein kinase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005158 IDA:RGDFinsulin receptor binding
GO:0016004 IEA:EnsemblFphospholipase activator activity
GO:0019901 IDA:RGDFprotein kinase binding
GO:0032148 IEA:EnsemblPactivation of protein kinase B activity
GO:0019722 IEA:EnsemblPcalcium-mediated signaling
GO:0016477 IEA:EnsemblPcell migration
GO:0071364 IEA:EnsemblPcellular response to epidermal growth factor stimulus
GO:0032869 IEA:EnsemblPcellular response to insulin stimulus
GO:0007173 IEA:EnsemblPepidermal growth factor receptor signaling pathway
GO:0097191 IEA:EnsemblPextrinsic apoptotic signaling pathway
GO:0048041 IMP:RGDPfocal adhesion assembly
GO:0006972 IEA:EnsemblPhyperosmotic response
GO:0010667 IEA:EnsemblPnegative regulation of cardiac muscle cell apoptotic process
GO:0006469 IEA:EnsemblPnegative regulation of protein kinase activity
GO:0034122 IEA:EnsemblPnegative regulation of toll-like receptor signaling pathway
GO:0030512 IEA:EnsemblPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0018107 IEA:EnsemblPpeptidyl-threonine phosphorylation
GO:0090004 IEA:EnsemblPpositive regulation of establishment of protein localization to plasma membrane
GO:0010518 IEA:EnsemblPpositive regulation of phospholipase activity
GO:0051281 IEA:EnsemblPpositive regulation of release of sequestered calcium ion into cytosol
GO:0010594 IEA:EnsemblPregulation of endothelial cell migration
GO:0043122 IEA:EnsemblPregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043304 IEA:EnsemblPregulation of mast cell degranulation
GO:0006355 IEA:UniProtKB-KWPregulation of transcription, DNA-templated
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0003323 IEA:EnsemblPtype B pancreatic cell development
KEGG Pathway Links
KEGG Pathway IDDescription
ko04960Aldosterone-regulated sodium reabsorption
rno04960Aldosterone-regulated sodium reabsorption
ko04152AMPK signaling pathway
rno04152AMPK signaling pathway
ko05213Endometrial cancer
rno05213Endometrial cancer
ko04664Fc epsilon RI signaling pathway
rno04664Fc epsilon RI signaling pathway
ko04510Focal adhesion
rno04510Focal adhesion
rno04068FoxO signaling pathway
ko05160Hepatitis C
rno05160Hepatitis C
ko04910Insulin signaling pathway
rno04910Insulin signaling pathway
ko04150mTOR signaling pathway
rno04150mTOR signaling pathway
ko04722Neurotrophin signaling pathway
rno04722Neurotrophin signaling pathway
ko05223Non-small cell lung cancer
rno05223Non-small cell lung cancer
ko04151PI3K-Akt signaling pathway
rno04151PI3K-Akt signaling pathway
ko03320PPAR signaling pathway
rno03320PPAR signaling pathway
ko05215Prostate cancer
rno05215Prostate cancer
ko05205Proteoglycans in cancer
rno05205Proteoglycans in cancer
ko04660T cell receptor signaling pathway
rno04660T cell receptor signaling pathway
rno04919Thyroid hormone signaling pathway
ko05145Toxoplasmosis
rno05145Toxoplasmosis
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953605Activation of NMDA receptor upon glutamate binding and postsynaptic events
5953521Activation of PKB
5953415Adaptive Immune System
5953991CD28 co-stimulation
5953990CD28 dependent PI3K/Akt signaling
5954570Constitutive PI3K/AKT Signaling in Cancer
5953992Costimulation by the CD28 family
5954295CREB phosphorylation through the activation of Ras
5954174CTLA4 inhibitory signaling
5953408DAP12 interactions
5953407DAP12 signaling
5953253Disease
5953994Downstream signaling events of B Cell Receptor (BCR)
5953399Downstream signaling of activated FGFR
5953396Downstream signal transduction
5954035Downstream TCR signaling
5953417Fc epsilon receptor (FCERI) signaling
5954040FCERI mediated NF-kB activation
5953884GAB1 signalosome
5954002G beta:gamma signalling through PI3Kgamma
5953642GPCR downstream signaling
5954003G-protein beta:gamma signalling
5953651GPVI-mediated activation cascade
5953645Hemostasis
5953430IGF1R signaling cascade
5953410Immune System
5953409Innate Immune System
5953422Insulin receptor signalling cascade
5954112Integrin alphaIIb beta3 signaling
5953428IRS-mediated signalling
5953425IRS-related events
5953429IRS-related events triggered by IGF1R
5953277Neuronal System
5953606Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
5953394NGF signalling via TRKA from the plasma membrane
5953989PI3K/AKT activation
5953997PI3K/AKT Signaling in Cancer
5953885PI-3K cascade
5953432PI3K Cascade
5953996PI3K events in ERBB2 signaling
5953995PI3K events in ERBB4 signaling
5953993PIP3 activates AKT signaling
5953644Platelet activation, signaling and aggregation
5954113Platelet Aggregation (Plug Formation)
5953604Post NMDA receptor activation events
5953998Role of LAT2/NTAL/LAB on calcium mobilization
5954298RSK activation
5953403Signaling by EGFR
5953404Signaling by EGFR in Cancer
5953406Signaling by ERBB2
5953540Signaling by ERBB4
5953400Signaling by FGFR
5953401Signaling by FGFR in disease
5953391Signaling by GPCR
5953423Signaling by Insulin receptor
5953397Signaling by PDGF
5953541Signaling by SCF-KIT
5953414Signaling by the B Cell Receptor (BCR)
5953431Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5953420Signaling by VEGF
5953395Signalling by NGF
5953381Signal Transduction
5954036TCR signaling
5953276Transmission across Chemical Synapses
5953419VEGFA-VEGFR2 Pathway
5953418VEGFR2 mediated cell proliferation
5953999VEGFR2 mediated vascular permeability