LMPD Database

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LMP012772

UniProt Annotations

Entry Information
Gene Namearginyl aminopeptidase (aminopeptidase B)
Protein EntryAMPB_RAT
UniProt IDO09175
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityRelease of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 zinc ion per subunit. ;
FunctionExopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4).
SimilarityBelongs to the peptidase M1 family
Subcellular LocationSecreted.
SubunitMonomer.
Tissue SpecificityWidely expressed.