LMPD Database

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LMP012774

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase zeta
Protein EntryDGKZ_RAT
UniProt IDO08560
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
FunctionDisplays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity)
InteractionQ62696:Dlg1; NbExp=4; IntAct=EBI-8570505, EBI-389325; Q63622:Dlg2; NbExp=4; IntAct=EBI-8570505, EBI-396947; Q62936:Dlg3; NbExp=4; IntAct=EBI-8570505, EBI-349596; P31016:Dlg4; NbExp=6; IntAct=EBI-8570505, EBI-375655;
SimilarityBelongs to the eukaryotic diacylglycerol kinase family
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers
Subcellular LocationCytoplasm . Nucleus {ECO:0000269|PubMed:8855332}. Cell membrane .
SubunitInteracts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Forms a signaling complex with RASGRP1 and HRAS (By similarity)