LMPD Database

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LMP012777

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol synthase 1
Protein EntryCDS1_RAT
UniProt IDO35052
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityCTP + phosphatidate = diphosphate + CDP- diacylglycerol.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
FunctionProvides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity). May play an important role in phosphoinositide synthesis, prefers 1-stearoyl-2-arachidonoyl phosphatidic acid as substrate
InductionActivated by GTP. Inhibited by CDP-diacylglycerol (product inhibition).
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
SimilarityBelongs to the CDS family
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Note=Cytoplasmic aspect of the endoplasmic reticulum.
SubunitInteracts with FOS; this interaction may enhance catalytic activity
Tissue SpecificityBrain, retina and testis. Found in cerebellar Purkinje cells, pineal body, inner segment of photoreceptor cells and postmitotic spermatocytes and spermatids.