LMPD Database

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LMP012788

UniProt Annotations

Entry Information
Gene Nameretinoid X receptor gamma
Protein EntryRXRG_RAT
UniProt IDQ5BJR8
SpeciesRat
Comments
Comment typeDescription
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitHomodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer
Tissue SpecificityResticted expression in adrenal gland, kidney, liver, brain and lungs. Strong expression in heart and lungs