LMPD Database

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LMP012800

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 5, group A, member 1
Protein EntrySTF1_RAT
UniProt IDP50569
SpeciesRat
Comments
Comment typeDescription
FunctionTranscriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)
PtmAcetylation stimulates the transcriptional activity
PtmPhosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity)
PtmSumoylation reduces CDK7-mediated phosophorylation on Ser- 203
SimilarityBelongs to the nuclear hormone receptor family. NR5 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus.
SubunitBinds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2, NCOA2 and PPARGC1A. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3 (By similarity)