LMPD Database

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LMP012806

UniProt Annotations

Entry Information
Gene Namesynaptojanin 2
Protein EntrySYNJ2_RAT
UniProt IDO55207
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=2B2; IsoId=O55207-1; Sequence=Displayed; Name=2B1; IsoId=O55207-2; Sequence=VSP_012914; Name=2A; Synonyms=7.5kb; IsoId=O55207-3; Sequence=VSP_012915, VSP_012916; Note=The PDZ domain of isoform 2A binds SYNJ2BP/OMP25. Mutagenesis of Ser-1246 or Val-1248 to Ala abolishes SYNJ2BP/OMP25 binding.; Name=7.2kb; IsoId=O55207-4; Sequence=Not described; Name=6.0kb; IsoId=O55207-5; Sequence=Not described; Name=5.2kb; IsoId=O55207-6; Sequence=Not described; Name=3.5kb; IsoId=O55207-7; Sequence=Not described;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
FunctionInositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity)
InteractionQ9WVJ4:Synj2bp; NbExp=9; IntAct=EBI-7007476, EBI-7007454;
SimilarityBelongs to the synaptojanin family
SimilarityContains 1 RRM (RNA recognition motif) domain
SimilarityContains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
SimilarityIn the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family
Subcellular LocationCytoplasm . Cell membrane . Note=Rac1 causes translocation from cytosol to the plasma membrane.
Subcellular LocationIsoform 2A: Mitochondrion. Note=Interaction of isoform 2A with SYNJ2BP/OMP25 results in localization to the mitochondrion.
SubunitBinds to GRB2 (By similarity). Isoform 2A binds to SYNJ2BP/OMP25
Tissue SpecificityWidely expressed. Isoforms 2B1 and 2B2 are concentrated at nerve terminals in brain and at spermatid manchette in testis.