LMPD Database

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LMP012807

UniProt Annotations

Entry Information
Gene Nameprostaglandin E receptor 4 (subtype EP4)
Protein EntryPE2R4_RAT
UniProt IDP43114
SpeciesRat
Comments
Comment typeDescription
CautionWas originally designated as the EP2 subtype
FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
PtmPhosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with FEM1A