LMPD Database

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LMP012812

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group I, member 2
Protein EntryNR1I2_RAT
UniProt IDQ9R1A7
SpeciesRat
Comments
Comment typeDescription
FunctionNuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand- binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity)
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
SubunitHeterodimer with RXRA. Interacts with NCOA1 (By similarity)