LMPD Database

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LMP012817

UniProt Annotations

Entry Information
Gene Namediacylglycerol O-acyltransferase 1
Protein EntryDGAT1_RAT
UniProt IDQ9ERM3
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Catalytic ActivityAcyl-CoA + retinol = CoA + retinyl ester.
FunctionCatalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol (By similarity)
PathwayLipid metabolism; glycerolipid metabolism.
SimilarityBelongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
SubunitHomodimer or homotetramer