LMPD Database

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LMP012819

UniProt Annotations

Entry Information
Gene Namephospholipase C-like 1
Protein EntryPLCL1_RAT
UniProt IDQ62688
SpeciesRat
Comments
Comment typeDescription
CautionIn the PI-PLC X-box Asn-459 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity
FunctionInvolved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as a inhibitor of PPP1C. {ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:8546702}.
PtmPhosphorylation of Thr-94 resulted in dissociation of PPP1C from PRIP1 (By similarity). In vitro, phosphorylated by the catalytic subunit of PKA. {ECO:0000250, ECO:0000269|PubMed:11278544}.
SimilarityBelongs to the PRIP family
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:8546702}.
SubunitInteracts with PPP2CA, GABA receptor beta subunits, GABA receptor gamma-2 subunits (By similarity). Interacts with Ins(1,4,5)P3, Ins(1,4,5,6)P4, GABARAP, and PPP1C. May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination. {ECO:0000250, ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:11867528, ECO:0000269|PubMed:8546702}.
Tissue SpecificityExpressed in brain. Found in the granular cell and Purkinje cell layers in the cerebellum; and in the hippocampal pyramidal cells, dentate granule cells and pyramidal granule cells of the cerebral cortex in the cerebrum