LMPD Database

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LMP012825

UniProt Annotations

Entry Information
Gene Name2-hydroxyacyl-CoA lyase 1
Protein EntryHACL1_RAT
UniProt IDQ8CHM7
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=15 uM for 2-hydroxy-3-methylhexadecanoyl-CoA ; pH dependence: Optimum pH is 7.5-8. ;
Catalytic Activity2-hydroxyphytanoyl-CoA = pristanal + formyl- CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 1 Mg(2+) ion per subunit. ;
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence= ; Note=Binds 1 thiamine pyrophosphate per subunit. ;
FunctionCatalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
PathwayLipid metabolism; fatty acid metabolism.
SimilarityBelongs to the TPP enzyme family
Subcellular LocationPeroxisome .
SubunitHomotetramer